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please try againinclude error,path:/comp/breadcrumb/nav?compId=breadcrumb_nav-1553751531669 cause:org.springframework.web.util.NestedServletException: Request processing failed; nested exception is java.lang.RuntimeException: org.springframework.transaction.CannotCreateTransactionException: Could not open JDBC Connection for transaction; nested exception is java.sql.SQLException: java.sql.SQLException: An attempt by a client to checkout a Connection has timed out. org.springframework.transaction.CannotCreateTransactionException: Could not open JDBC Connection for transaction; nested exception is java.sql.SQLException: java.sql.SQLException: An attempt by a client to checkout a Connection has timed out. at org.springframework.jdbc.datasource.DataSourceTransactionManager.doBegin(DataSourceTransactionManager.java:245) at org.springframework.transaction.support.AbstractPlatformTransactionManager.getTransaction(AbstractPlatformTransactionManager.java:373) at org.springframework.transaction.interceptor.TransactionAspectSupport.createTransactionIfNecessary(TransactionAspectSupport.java:426) at org.springframework.transaction.interceptor.TransactionAspectSupport.invokeWithinTransaction(TransactionAspectSupport.java:275) at org.springframework.transaction.interceptor.TransactionInterceptor.invoke(TransactionInterceptor.java:96) at org.springframework.aop.framework.ReflectiveMethodInvocation.proceed(ReflectiveMethodInvocation.java:179) at org.springframework.aop.interceptor.ExposeInvocationInterceptor.invoke(ExposeInvocationInterceptor.java:92) at org.springframework.aop.framework.ReflectiveMethodInvocation.proceed(ReflectiveMethodInvocation.java:179) at org.springframework.aop.framework.JdkDynamicAopProxy.invoke(JdkDynamicAopProxy.java:213) at com.sun.proxy.$Proxy98.getAppByAppId(Unknown Source) at com.alibaba.dubbo.common.bytecode.Wrapper3.invokeMethod(Wrapper3.java) at com.alibaba.dubbo.rpc.proxy.javassist.JavassistProxyFactory$1.doInvoke(JavassistProxyFactory.java:45) at com.alibaba.dubbo.rpc.proxy.AbstractProxyInvoker.invoke(AbstractProxyInvoker.java:71) at com.alibaba.dubbo.config.invoker.DelegateProviderMetaDataInvoker.invoke(DelegateProviderMetaDataInvoker.java:48) at com.alibaba.dubbo.rpc.protocol.InvokerWrapper.invoke(InvokerWrapper.java:52) at com.alibaba.csp.sentinel.adapter.dubbo.SentinelDubboProviderFilter.invoke(SentinelDubboProviderFilter.java:66) at com.alibaba.dubbo.rpc.protocol.ProtocolFilterWrapper$1.invoke(ProtocolFilterWrapper.java:68) at com.alibaba.dubbo.rpc.filter.ExceptionFilter.invoke(ExceptionFilter.java:61) at com.alibaba.dubbo.rpc.protocol.ProtocolFilterWrapper$1.invoke(ProtocolFilterWrapper.java:68) at com.alibaba.dubbo.rpc.filter.TimeoutFilter.invoke(TimeoutFilter.java:41) at com.alibaba.dubbo.rpc.protocol.ProtocolFilterWrapper$1.invoke(ProtocolFilterWrapper.java:68) at com.alibaba.dubbo.monitor.support.MonitorFilter.invoke(MonitorFilter.java:74) at com.alibaba.dubbo.rpc.protocol.ProtocolFilterWrapper$1.invoke(ProtocolFilterWrapper.java:68) at com.alibaba.dubbo.rpc.protocol.dubbo.filter.TraceFilter.invoke(TraceFilter.java:77) at com.alibaba.dubbo.rpc.protocol.ProtocolFilterWrapper$1.invoke(ProtocolFilterWrapper.java:68) at com.alibaba.dubbo.rpc.filter.ContextFilter.invoke(ContextFilter.java:71) at com.alibaba.dubbo.rpc.protocol.ProtocolFilterWrapper$1.invoke(ProtocolFilterWrapper.java:68) at com.alibaba.dubbo.rpc.filter.GenericFilter.invoke(GenericFilter.java:131) at com.alibaba.dubbo.rpc.protocol.ProtocolFilterWrapper$1.invoke(ProtocolFilterWrapper.java:68) at com.alibaba.dubbo.rpc.filter.ClassLoaderFilter.invoke(ClassLoaderFilter.java:37) at com.alibaba.dubbo.rpc.protocol.ProtocolFilterWrapper$1.invoke(ProtocolFilterWrapper.java:68) at com.alibaba.dubbo.rpc.filter.EchoFilter.invoke(EchoFilter.java:37) at com.alibaba.dubbo.rpc.protocol.ProtocolFilterWrapper$1.invoke(ProtocolFilterWrapper.java:68) at com.alibaba.dubbo.rpc.protocol.dubbo.DubboProtocol$1.reply(DubboProtocol.java:98) at com.alibaba.dubbo.remoting.exchange.support.header.HeaderExchangeHandler.handleRequest(HeaderExchangeHandler.java:96) at com.alibaba.dubbo.remoting.exchange.support.header.HeaderExchangeHandler.received(HeaderExchangeHandler.java:168) at com.alibaba.dubbo.remoting.transport.DecodeHandler.received(DecodeHandler.java:50) at com.alibaba.dubbo.remoting.transport.dispatcher.ChannelEventRunnable.run(ChannelEventRunnable.java:79) at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1145) at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:615) at java.lang.Thread.run(Thread.java:745) Caused by: java.sql.SQLException: java.sql.SQLException: An attempt by a client to checkout a Connection has timed out. at cn.ce.ebiz.framework.persistence.TenantDataSource.getConnection(TenantDataSource.java:137) at org.springframework.jdbc.datasource.DataSourceTransactionManager.doBegin(DataSourceTransactionManager.java:204) ... 40 more Caused by: java.sql.SQLException: An attempt by a client to checkout a Connection has timed out. at com.mchange.v2.sql.SqlUtils.toSQLException(SqlUtils.java:106) at com.mchange.v2.sql.SqlUtils.toSQLException(SqlUtils.java:65) at com.mchange.v2.c3p0.impl.C3P0PooledConnectionPool.checkoutPooledConnection(C3P0PooledConnectionPool.java:527) at com.mchange.v2.c3p0.impl.AbstractPoolBackedDataSource.getConnection(AbstractPoolBackedDataSource.java:128) at org.springframework.jdbc.datasource.lookup.AbstractRoutingDataSource.getConnection(AbstractRoutingDataSource.java:164) at cn.ce.ebiz.framework.persistence.TenantDataSource.getConnection(TenantDataSource.java:111) ... 41 more Caused by: com.mchange.v2.resourcepool.TimeoutException: A client timed out while waiting to acquire a resource from com.mchange.v2.resourcepool.BasicResourcePool@2f4bd2e5 -- timeout at awaitAvailable() at com.mchange.v2.resourcepool.BasicResourcePool.awaitAvailable(BasicResourcePool.java:1317) at com.mchange.v2.resourcepool.BasicResourcePool.prelimCheckoutResource(BasicResourcePool.java:557) at com.mchange.v2.resourcepool.BasicResourcePool.checkoutResource(BasicResourcePool.java:477) at com.mchange.v2.c3p0.impl.C3P0PooledConnectionPool.checkoutPooledConnection(C3P0PooledConnectionPool.java:525) ... 44 more
凌科药业宣布其血液肿瘤靶向抑制剂LNK01002正式获得美国FDA许可开展临床试验
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摘要:
凌科药业于美国时间11月4日正式宣布,其自主开发的用于血液肿瘤的靶向抑制剂LNK01002正式获得美国食品药品监督管理局(FDA)许可开展Ⅰ期临床试验。
日本理研和神户大学授权凌科药业独家开发新型RAS抑制剂
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摘要:
中国杭州2020年7月27日 /美通社/ -- 凌科药业(中国杭州)欣然宣布与日本神户大学(Kobe University)和日本理化学研究所(RIKEN Research Institute,简称RIKEN)签署独家授权协议,以开发具有新型药物作用机制(MOA)的RAS抑制剂。同时,凌科药业与神户大学签署的协议中还包括神户大学继续提供活性筛选和结构的技术支持。
凌科药业成功完成海外技术转让
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发布时间:
2020-06-29 13:28
摘要:
2020年4月1日, 凌科药业成功完成一个临床前项目技术转让给一个美国公司;首付款和里程碑付款近两亿美元以及高达两位数(百分比)的销售提成
中国科学院肿瘤与基础医学研究所与凌科药业签约建立新药研发中心
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摘要:
5月8日,中国科学院肿瘤与基础医学研究所与凌科药业签约建立新药研发中心
凌科药业宣布完成数千万美元A轮融资
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摘要:
凌科药业宣布完成数千万美元A轮融资
凌科药业SPF级实验动物房通过验收
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发布时间:
2019-12-12 17:27
摘要:
凌科药业实验动物中心通过浙江省实验动物管理委员会办公室的现场验审核,并于2019年12月6日获得了实验动物使用许可证
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